David A Dean Selected Research

Congenital Deficiency of Pulmonary Surfactant Protein B

1/2017

Featured Article: Electroporation-mediated gene delivery of surfactant protein B (SP-B) restores expression and improves survival in mouse model of SP-B deficiency.

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David A Dean Research Topics

Disease

6	Edema (Dropsy) 01/2015 - 07/2002
5	Inflammation (Inflammations) 01/2021 - 01/2002
5	Lung Injury 11/2013 - 06/2005
4	Acute Lung Injury 10/2021 - 03/2007
4	Hyperoxia 09/2010 - 05/2002
3	Pulmonary Edema 10/2021 - 09/2007
3	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 12/2019 - 11/2013
3	Sepsis (Septicemia) 01/2019 - 08/2012
2	Lung Diseases (Lung Disease) 01/2021 - 01/2017
2	Wounds and Injuries (Trauma) 12/2019 - 01/2002
2	Thrombosis (Thrombus) 10/2015 - 10/2007
1	Myotonic Dystrophy (Dystrophia Myotonica) 01/2021
1	Persistent Fetal Circulation Syndrome 01/2020
1	Cicatrix (Scar) 12/2019
1	Idiopathic Pulmonary Fibrosis 12/2019
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2019
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2017
1	Congenital Deficiency of Pulmonary Surfactant Protein B 01/2017
1	Aortic Coarctation 12/2016
1	Hemolysis 10/2015
1	Stroke (Strokes) 05/2015
1	Heart Failure 05/2015
1	Neoplasms (Cancer) 01/2015
1	Ventilator-Induced Lung Injury 11/2013
1	Ischemia 01/2013
1	Bronchopulmonary Dysplasia 08/2012
1	Fibrosis (Cirrhosis) 08/2012
1	Infections 08/2012
1	Pneumonia (Pneumonitis) 08/2012
1	Virus Diseases (Viral Diseases) 08/2012
1	Emphysema 06/2012
1	Chronic Obstructive Pulmonary Disease (COPD) 06/2012
1	Premature Aging 06/2012
1	Atherosclerosis 02/2010
1	Renal Insufficiency (Renal Failure) 01/2010
1	Hypertrophy 01/2010
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2010
1	Albuminuria 01/2010
1	Atrial Fibrillation 08/2009
1	Hypoglycemia (Reactive Hypoglycemia) 09/2007
1	Coronary Disease (Coronary Heart Disease) 09/2007

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2002
5	Surface-Active Agents (Surfactants)IBA 01/2017 - 10/2009
3	Adenosine Triphosphatases (ATPase)IBA 01/2015 - 03/2007
3	Oxygen (Dioxygen)IBA 08/2012 - 10/2009
2	Thrombin FDA Link 01/2019 - 10/2007
2	Glucose (Dextrose)FDA LinkGeneric 01/2010 - 09/2007
2	Interleukin-6 (Interleukin 6)IBA 10/2007 - 01/2002
2	CytokinesIBA 10/2007 - 03/2007
1	Tight Junction ProteinsIBA 10/2021
1	LipopolysaccharidesIBA 10/2021
1	Protein Kinases (Protein Kinase)IBA 01/2021
1	AllergensIBA 01/2021
1	Pharmaceutical PreparationsIBA 01/2021
1	Phosphotransferases (Kinase)IBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2020
1	Bleomycin (Blenoxane)FDA LinkGeneric 12/2019
1	Caveolin 1IBA 12/2019
1	Extracellular Matrix ProteinsIBA 12/2019
1	InflammasomesIBA 12/2019
1	Beclin-1IBA 01/2019
1	IgA receptor (protein B)IBA 01/2017
1	Messenger RNA (mRNA)IBA 12/2016
1	VaccinesIBA 01/2015
1	EnzymesIBA 01/2015
1	FibrinIBA 01/2015
1	Epithelial Sodium ChannelsIBA 01/2015
1	Cadherins (E-Cadherin)IBA 01/2013
1	GasesIBA 01/2013
1	Pulmonary Surfactant-Associated Protein A (Surfactant Protein A)IBA 01/2013
1	salicylhydroxamic acid (SHAM)IBA 01/2013
1	Anti-Bacterial Agents (Antibiotics)IBA 08/2012
1	Histone Deacetylases (Histone Deacetylase)IBA 06/2012
1	SmokeIBA 06/2012
1	SRT1720IBA 06/2012
1	NAD (NADH)IBA 06/2012
1	Sirtuin 1IBA 06/2012
1	Pancreatic Elastase (Elastase)IBA 06/2012
1	Protein Isoforms (Isoforms)IBA 09/2010
1	8-hydroxyguanineIBA 09/2010
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 02/2010
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2010
1	GTP-Binding Proteins (G-Protein)IBA 08/2009
1	Particulate MatterIBA 10/2007
1	Thromboplastin (Tissue Factor)IBA 10/2007
1	Prothrombin (Factor II)IBA 10/2007
1	Fibrinogen (Factor I)FDA Link 10/2007
1	EndotoxinsIBA 09/2007
1	Peptides (Polypeptides)IBA 09/2007
1	Insulin (Novolin)FDA Link 09/2007

Therapy/Procedure

6	Therapeutics 12/2019 - 09/2007
3	Artificial Respiration (Mechanical Ventilation) 11/2013 - 06/2005
2	Continuous Positive Airway Pressure 11/2013 - 01/2013
1	RNAi Therapeutics 12/2019
1	Lung Transplantation 01/2017
1	Heart-Assist Devices 10/2015
1	Transplantation 05/2015
1	Positive-Pressure Respiration (Positive End-Expiratory Pressure) 11/2013
1	Anesthesia 08/2012
1	Mechanical Ventilators (Ventilator) 08/2012